![]() ![]() ![]() ![]() The ternary polymer featured efficient DNA condensation to favor cellular internalization, and the acidic environment in the endolysosomes triggered effective degradation of the polymer to promote the cargo release. A series of polyphenols including ellagic acid (EA), epigallocatechin gallate (EGCG), nordihydroguaiaretic acid (NDGA), rutin (RT), and rosmarinic acid (RA), and APBA molecules including 2-acetylphenylboric acid (2-APBA), 3-acetylphenylboric acid (3-APBA), and 4-acetylphenylboric acid (4-APBA), were screened, and the best-performing 2-PEI-RT constructed from RT and 2-APBA was identified. During the one-pot synthesis of the ternary polymer, acetylphenylboric acid (APBA), polyphenol, and low-molecular weight polyethyleneimine (PEI 1.8k) were dynamically crosslinked with each other due to formation of imine between PEI 1.8k and APBA and formation of boronate ester between APBA and polyphenol. Herein, a series of ternary polymers were synthesized via facile green chemistry to achieve efficient plasmid DNA and mRNA delivery in serum. Cationic polymers used for nucleic acid delivery often suffer from complicated syntheses, undesired intracellular cargo release, and low serum stability. ![]()
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